November 28, 2022

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NanoString to Unveil New Platforms and Showcase Spatial Biology Research at 2022 Advances in Genome Biology and Technology (AGBT) General Meeting

Dwell webcast of Spatial Multiomic Symposium on Monday, June 6, from noon to 4 pm EDT

Information from 20 scientific reports highlight the use of NanoString’s spatial biology platforms

SEATTLE, June 02, 2022–(Enterprise WIRE)–NanoString Systems, Inc. (NASDAQ: NSTG), a leading supplier of lifestyle science equipment for discovery and translational exploration, currently declared designs to commercially unveil the CosMx™ Spatial Molecular Imager (SMI) and its new spatial informatics portal in the course of a Spatial Multiomic Symposium, which will be held on Monday, June 6 from noon to 4:00 pm EDT. The event will be live-streamed and held in human being, and information can be identified below: Spatial Multiomics Symposium – NanoString. In addition, experts will current 20 scientific tests demonstrating the energy of NanoString spatial biology platforms all through the scientific part of the AGBT Normal Meeting.

CosMx SMI permits higher-resolution imaging of extra than 1,000 RNA and more than 100 protein analytes inside of morphologically intact entire tissue sections. The technological know-how combines the energy of superior-plex profiling with higher-resolution imaging, allowing researchers to visualize and quantify gene and protein expression at one mobile and subcellular resolutions in equally contemporary frozen and formalin-set paraffin-embedded (FFPE) tissue samples. CosMx SMI serves researchers across the continuum of research using a tunable workflow that can prioritize both impartial complete-slide imaging at superior-plex for discovery or significant-throughput biology-pushed assessment for translation.

NanoString is dedicated to building spatial biology solutions for any scale of exploration. The GeoMx DSP is the main system for measuring total transcriptome at large-throughput in multi-mobile useful locations and the CosMx SMI extends ability to single cell and subcellular resolution throughout the whole tissue area. Jointly, GeoMx DSP and CosMx SMI technologies offer unparalleled scientific energy for novel spatial discoveries.

Spatial biology experiments are data-intensive, making up to 1 terabyte of knowledge for each sample. NanoString is acquiring a new cloud-based mostly spatial informatics portal that will supply researchers with a scalable resolution to store substantial GeoMx and CosMx datasets, lower compute instances, and allow protected information sharing and collaboration across institutes.

The Spatial Multiomic Symposium will showcase the software of these highly effective instruments to resolve biological heterogeneity. Attendees will master about the most up-to-date innovations and will have the chance to hear how main specialists are making use of these technologies to make novel discoveries in immunology, infectious diseases, oncology and neuroscience.

“We believe spatial biology is the following revolution in life sciences, and we’re honored to provide collectively experts to showcase cutting-edge spatial technologies and methods,” mentioned Brad Gray, president and CEO, NanoString Technologies. “The volume and good quality of NanoString-pushed science becoming presented at AGBT 2022 is a testament to the electrical power of our spatial biology ecosystem.”

The Spatial Multiomic Summit Agenda: Speakers and Scientific Displays

  • Keynote: Spatial gene expression variations in human skin biology induced from spaceflight: Christopher Mason, Ph.D., Professor Director, WorldQuant Initiative for Quantitative Prediction Physiology and Biophysics, Weill Cornell Drugs

  • Spatially fixed, single mobile atlas of human pancreatic islets of Langerhans in style 2 diabetic and nutritious controls: Grant Kolar, M.D., Ph.D., Assistant Investigate Professor Director, Research Microscopy and Histology Main, St. Louis University

  • Deep spatiotemporal insights into COVID-19: a multi-organ research: Arutha Kulasinghe, Ph.D., Nationwide Overall health and Health care Investigate Council Exploration Fellow, The University of Queensland

  • Spatial reconstruction of joint swelling in rheumatoid arthritis: Kevin Wei, M.D., Ph.D., Assistant Professor of Drugs, Brigham and Women’s Hospital

  • Spatially fixed Alzheimer’s ailment in mouse design: Miranda Orr, Ph.D., Assistant Professor, Gerontology and Geriatric Medicine, Wake Forest College School of Drugs

To master extra and sign up for the celebration, make sure you pay a visit to: Spatial Multiomics Symposium – NanoString

At AGBT 2022, 20 posters and oral presentations will showcase special biological insights produced employing NanoString’s spatial platforms. These abstracts involve scientific studies discovering spatial biology utilizing the GeoMx DSP and the CosMx SMI platforms.

“As one-cell resolution spatial transcriptomics and proteomics pioneer the subsequent frontier in spatial biology, our comprehension of elementary processes in biology will deepen and most likely pave the way for next-era diagnostic and pathology equipment,” stated Joe Beechem, chief scientific officer, NanoString Systems. “The CosMx SMI technique is excellent for deeper single-mobile exploration downstream of whole transcriptome assessment carried out on GeoMx DSP and the two techniques can essentially be applied for complementary experiments on a established of samples.”

A number of studies and displays that function NanoString’s spatial biology platforms are highlighted underneath.

Oral Presentations

Multicellular spatial neighborhoods in pancreatic cancer reworked by neoadjuvant therapy will be introduced by Will Hwang, M.D., Ph.D., radiation oncologist and investigate fellow, Massachusetts Typical Healthcare facility Most cancers Middle/Harvard Medical School, on June 6 from 6:05-6:25 pm. Discover the special interaction concerning malignant cells and nerves/microenvironment in the course of the reaction to remedy for PDAC, working with GeoMx DSP and CosMx SMI platforms.

Constructing a spatial one-cell multi-omics atlas and mobile interactome for skin most cancers will be offered by Quan Nguyen, Ph.D., the University of Queensland on June 7 from 7:50-8:10 pm. Understand how CosMx profiling allows spatial interactome investigation that gives new insights in the growth of pores and skin most cancers. This will be a comparison of 6 spatial platforms.

Substantial-plex (> 1000), multi-omic (RNA plus protein), spatial molecular imaging with sub-cellular resolution in FFPE tissue, will be presented by Joe Beechem, Ph.D., chief scientific officer, NanoString Technologies. Concurrent periods will run from 8:50-9:10 pm on June 8. Find out how substantial-plex multi-omic (RNA and protein) targets detected in FFPE samples making use of CosMx SMI, at subcellular and one-mobile resolution in >1 million cells from a one slide uncovers novel biological insights that had been formerly lost in place.

Scientific Posters

Poster: Spatial characterization of the tumor microenvironment in pancreatic cancer with complete transcriptome profiling and substantial plex single-cell imaging.
David Ting, M.D., Chief Healthcare Information and facts Officer, Mass Basic Doctors Organization, Co-Director, MGH Centre for Innovation in Digital Health care, Assistant Professor, Harvard Healthcare School
See the origin of exosomes in tumor microenvironments and the influence of their migrations in pancreatic most cancers tissues using the CosMx SMI platform.

Poster: Characterization of human mind organoids with one-cell resolution and molecular specificity
Florent Ginhoux, Ph.D., Senior Principal Investigator · Singapore Immunology Community, Agency for Science, Technological innovation and Study
Learn how CosMx one-mobile imager allows exceptional analyses and understanding of human brain organoid cells in area.

Poster: Spatially-mapped quantitative single-cell characterization of PD-L1-related RNA microenvironments in triple-destructive breast most cancers
Aubrey Thompson, Ph.D., Co-director of the Mayo Clinic Breast Cancer Translational Genomics Application
Understand how CosMx and GeoMx spatial platforms crank out consistent information for clinical biomarkers of response to IO remedy.

Poster: Spatial Solitary Mobile characterization of SIV reservoirs in lymphoid tissues and B mobile follicles in rhesus macaques
Jake Estes, Ph.D., Professor, VGTI-Vaccine and Gene Remedy Institute Chief, Division of Pathobiology & Immunology, Oregon Nationwide Primate Analysis Center
Uncover how subcellular localization of SIV RNAs in NHP discovered by CosMx and reaction to drug targets in contaminated-cell microenvironments studied applying GeoMx DSP offers novel investigation tools for vaccine progress.

Poster: Substantial-plex spatial single mobile in situ evaluation of lung SARS-CoV-2
Arutha Kulasinghe, Ph.D., NHMRC Study Fellow, Queensland College of Technology
Find out the constant insights in COVID biology and biomarkers uncovered by the CosMx SMI and GeoMx DSP platforms at different scales.

To see the complete list of 2022 AGBT posters and discover far more about the data presented on the GeoMx DSP and CosMx SMI platforms, check out NanoString’s AGBT celebration site.

About NanoString Technologies, Inc.

NanoString Systems is a top provider of existence science instruments for discovery and translational exploration. The organization provides a few platforms that make it possible for scientists to map the universe of biology. The nCounter® Analysis Technique, cited in far more than 5,300 peer-reviewed publications, features a way to quickly profile the expression of hundreds of genes, proteins, miRNAs, or duplicate range variations, at the same time with superior sensitivity and precision. NanoString’s GeoMx® Digital Spatial Profiler enables very multiplexed spatial profiling of RNA and protein targets in a variety of sample types, which includes FFPE tissue sections, and has been cited in more than 120 peer-reviewed publications. The CosMx™ Spatial Molecular Imager, with business availability envisioned in 2022, permits remarkably sensitive, large-resolution imaging of hundreds to 1000’s of RNAs or proteins right from one cells in morphologically intact total tissue sections. For far more facts, pay a visit to www.nanostring.com.

Forward-Wanting Statements

This information launch consists of forward-looking statements in the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Trade Act of 1934 and the Private Securities Litigation Reform Act of 1995. These ahead-on the lookout statements consist of statements about our items and the expected launch of new merchandise and technological innovation. These types of statements are primarily based on current assumptions that entail dangers and uncertainties that could induce true results and final results to vary materially. These hazards and uncertainties, quite a few of which are past our control, consist of market acceptance of our merchandise the extent and length of the impression of the COVID-19 pandemic and adverse disorders in the general domestic and worldwide financial marketplaces the results of ongoing litigation the effects of level of competition the influence of expanded revenue, internet marketing, merchandise improvement and scientific pursuits on running expenses delays or other unforeseen troubles with regard to production and solution improvement as properly as the other challenges established forth in our filings with the Securities and Exchange Fee. These ahead-seeking statements discuss only as of the day hereof. NanoString Technologies disclaims any obligation to update these forward-on the lookout statements.

NanoString, NanoString Systems, the NanoString brand, CosMx, GeoMx, and nCounter are logos or registered emblems of NanoString Technologies, Inc. in many jurisdictions.

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